Rowett Research
Services

 Obesity and Metabolic Health Programme
 -Molecular Endocrinology Group

  Head of Group: Dr. Julian Mercer

Molecular
Endocrinology Group

Research Goals

• to investigate the extent to which childhood obesity is of physiological, behavioural or psychological origin

• to understand the mechanistic basis of protein-induced satiety

• to develop successful weight reduction strategies which produce a sustainable weight loss

The Molecular Endocrinology Group works with human volunteers within the Human Nutrition Unit and in the community. The Rascal study is collecting a unique database from pre-school children and their parents and siblings, with the potential for longitudinal tracking of body weight trajectories. Characterisation of the responses to dietary manipulation, and the confirmation and optimisation of dietary and activity interventions that reduce body weight, and keep that weight off, constitute another major component of the research activity. The research takes account of individual variability in phenotypic traits and susceptibility to, and route to, obesity, in recognition of the limitations of a ‘one-size-fits-all’ approach. In the future this may facilitate advice and intervention for individuals and defined sub-groups. The work will provide a scientific (mechanistic) basis for successful weight loss strategies enhancing the success of obesity treatment and the quality of life of those undergoing such treatment. The goal is the evolution of, and mechanistic characterisation of, effective long-term dietary and lifestyle interventions in adults, children and families. The ability of interventions to combat the deleterious co-morbidities that accompany obesity is also a critical issue.

Areas of Research within the Molecular Endocrinology Group

Hypothalamic control of body weight: novel pathways and mechanisms - Dr. Alexander Ross