Context of research |
Coronary heart disease (CHD), is still one of the main causes of death in the UK, and is an increasing problem worldwide.
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What problem is our research addressing? |
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Inappropriate diets are seen as an important cause of CHD and may underlie up to 30% of deaths from the disease.
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Identification of dietary compounds that most effectively prevent CHD is critical.
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Many issues relating to the intake of fatty acids remain unresolved, including the elucidation of their mechanism of actions.
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What research have we carried out on this topic? |
To assess by which mechanisms dietary fatty acids (like n-3 fatty acids, conjugated linoleic acids and fatty acids from olive oil) affect the development of heart disease in humans and animal models of atherosclerosis by:
• Measurement of validated risk markers for CHD
• Identification of new risk markers for CHD identified through proteomics
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What are the key findings of this research? |
Differential protein (pathway) regulation between dietary fatty acids and even between different isomers of the same dietary fatty acid
• Fish oils and cis9, trans 11-CLA induce anti-inflammatory and anti-atherogenic pathways.
• trans10, cis12-CLA induces pro-diabetic and pro-atherogenic pathways.
• Olive oils induces pro-diabetic, but also anti-oxidant and anti-atherogenic pathways.
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Differential protein regulation between different isomers of the same dietary fatty acid
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Differential protein regulation between dietary fatty acids
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What are the potential deliverables from this research? |
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Key References |
de Roos B, Mercer DK, Wainwright C, Thies F. Effect of long chain n-3 PUFA on endothelial activation, endothelial function and atheromatous plaque stability. Current Nutrition and Food Science 2005;1:167-77.
de Roos B, Rucklidge G, Reid M et al. Divergent mechanisms of cis9, trans11-and trans10, cis12-conjugated linoleic acid affecting insulin resistance and inflammation in apolipoprotein E knockout mice: a proteomics approach. FASEB J 2005;19:1746-8.
de Roos B, Duivenvoorden I, Rucklidge G et al. Response of apolipoprotein E*3-Leiden transgenic mice to dietary fatty acids: combining liver proteomics with physiological data. FASEB J 2005;19:813-5. |
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